Together with NASA astronaut Jessica Meir, Sophie will exit the International Space Station from the Quest airlock at approximately 13:30 BST/14:30 CEST to replace a spacecraft navigational aid, prepare a cosmic particle detector for future upgrades, install jumper cables to boost data-relay systems, and other tasks. Sophie and Jessica are expected to spend about six and a half hours outside the orbital complex.

Sophie exited the Station twice during August with NASA astronaut Anil Menon, for EVA-97 and EVA-98, to complete the replacement of a failed SGANT antenna.