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Even with regular exercise, astronaut's heart left smaller after a year in space

With NASA preparing to send humans to Mars in the 2030s, researchers are studying the physical effects of spending long periods in space. Now a new study by scientists at UT Southwestern shows that the heart of an astronaut who spent nearly a year aboard the International Space Station shrank, even with regular exercise, although it continued to function well.
The results were comparable with what the researchers found in a long-distance swimmer who spent nearly half a year trying to cross the Pacific Ocean.
The study, published today in Circulation, reports that astronaut Scott Kelly, now retired, lost an average of 0.74 grams—about three-tenths of an ounce—per week in the mass of his heart's left ventricle during the 340 days he spent in space, from March 27, 2015, to March 1, 2016. This occurred despite a weekly exercise regimen of six days of cycling, treadmill, or resistance work.